The Panigale V2 mounts two injectors per cylinder, one above and one below the throttle body, larger, and re-angled. Despite having the same flow rate, the intake ducts lose less pressure than their predecessors, improving intake efficiency.

The silencer boasts an internal layout that is better able to abate spikes in noise, back pressure remaining equal.

The Panigale V2 engine acts as a stressed member of the frame. Set 90° apart, the cylinders are banked rearwards around the crankshaft axis, resulting in a 21° angle between front cylinder and horizontal plane. The two cylinder heads and aluminium top covers feature a ribbed design to reduce mechanical noise. The crankcases are vacuum diecast using Vacural® technology to optimize weight saving and ensure consistent wall thickness and increased strength. The crankcase cover, clutch cover and sump are all in die-cast aluminum.

Transmission involves a six-speed gearbox with the Ducati Quick Shift up/down EVO system and a wet clutch. The latter comes complete with an anti-patter and progressive self-servo mechanism.

Attached directly to the cylinder heads, the monocoque frame houses the steering head bearings, contained in two aluminum bushes. In addition to working as a frame, the monocoque also serves as an air-box. It contains not just the air filter but also the throttle bodies and the fuel circuit, complete with injectors, and is sealed off by the aluminum fuel tank bottom.

The front-end geometry has 24° of rake and 94 mm of trail, while the double-sided swingarm has been replaced with a sophisticated, fully die-cast aluminum single-sided swingarm. The wheelbase is 1436 mm and the weight distribution is 52% at the front and 48% at the rear.

The Panigale V2 features the 43 mm Showa BPF fork at the front, fully adjustable in its spring pre-load, compression and rebound damping. The Showa Big Piston Fork (BPF) considerably improves damping control at low speed, ensuring lower-pressure oil feed and reducing the amount of fluid needed for compression and rebound adjustment.

The Panigale V2 has a 5-spoke, 3.5 inch wheel at the front and 5.5 inch wheel at the rear, both rolling on Pirelli Diablo Rosso IV Corsa tires, specifically 120/70 ZR17 at the front and 180/60 ZR17 at the rear. Pirelli's first multi-compound bike tyre, the Diablo Rosso IV Corsa combines racetrack performance with road versatility, making it ideal for the Panigale V2.

Instrumentation on the Panigale V2 features a 4.3" TFT display. The graphics and interface facilitate menu browsing and setting adjustment while allowing more immediate identification of the selected Riding Mode. The Riding Mode interface clearly and immediately shows any changes being made to the settings. This is done thanks to the explanatory graphics of the system being adjusted and a graduated scale indicating whether the modification is better suited to performance or vehicle safety/stability.

The comprehensive and modern electronic equipment, based on the 6-axis inertial platform, leaves no doubt that the Panigale V2 possesses the DNA of a high-end sports bike. The new electronics package raises active safety and dynamic control standards thanks to the ABS cornering function and quick shift up/down, in addition to traction control, engine brake control and wheelie control. All controls are integrated into the three Riding Modes (Race, Sport and Street) and can be adjusted via the 4.3" color TFT dashboard. Featuring a user-friendly graphic interface inspired by that of the Panigale V4, menu navigation, settings adjustment and identification of the selected Riding Mode couldn't be easier.

The front headlight assembly is extremely compact thanks to the adoption of two small LED low beam / high beam modules. The Daytime Running Light and the upper rim of the dual headlight assembly create a 'browed' look, the modern hallmark of Ducati sports bikes. At the rear, the full LED taillight features a two-part design as per Ducati sports tradition. The dual red arch of the side light makes the Panigale V2 both unmistakable and assertive. Front and rear LED indicators complete the lighting system.